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Studies of paleopolyploid plants have demonstrated that functional categories generally associated with higher network connectivity tend to be retained in duplicate following whole genome duplication (WGD) [ 28].
James Leebens-Mack, a plant geneticist at the University of Georgia in Athens, agrees: "We now need to determine whether certain types of genes tended to be retained in duplicate and investigate how functional evolution of these genes contributed to major innovations such as the origin of the seed".
The dosage balance hypothesis predicts that such genes are likely to be retained in duplicate after the WGD due to their many interactions (Veitia et al. 2008).
The now classical model of Ohno (1970) posits that genes will be retained in duplicate if one of the duplicates is released from evolutionary constraint and, under a neutral mutational model, acquires a new function.
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The loss or retention of certain classes of genes appears to be a recurrent pattern when ancient whole-genome duplication patterns are examined, although the classes that are retained in duplicate differ depending on the lineage under study [ 35, 36, 41, 68].
Some of such copies have been retained in duplicate through evolution [8].
Because of a round of genome duplication occurred at the base of teleosts radiation, several zebrafish genes have been retained in duplicate through evolution.
Genes involved in the development of pigment cells are retained in duplicate at a high rate.
Two loci were retained in duplicate for all polyploid individuals included in this study.
In Arabidopsis (Brassicaceae) and rice (Poaceae), however, genes involved with transcription were retained in duplicate [ 36].
Three of these loci were retained in duplicate for all individuals examined.
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