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Year of birth and postcode will however be retained for statistical purposes.
The quality criteria for H-MRS data to be retained for statistical analyses are the following: signal-to-noise ratio (SNR) of 15 or greater, computed from the amplitude of NAA divided by the standard deviation (SD) of the noise; linewidth (FWHM) of 8 Hz or less; and uncertainty in the estimation of the fit (Cramer Rao bounds) smaller than 10 %SD.
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Only peaks in the 5000 7400 Da mass range was retained for statistical analysis.
Volumes obtained from these tracings were retained for statistical analyses.
Following filtering and quality control 27458 probes were retained for statistical analysis.
Finally, 1,452 subjects with 658,288 autosomal SNPs were retained for statistical analyses, with an overall call rate of 99.68%.
As no technical reason could be identified for the occurrence of these outliers, all data were retained for statistical analysis in order to provide a conservative estimate of inhomogeneity for the materials.
Data filtering and normalisation were performed as previously for the ANOVA model and 7,452 and 8,561 probes were retained for statistical analysis of the Se and Sa challenges, respectively.
Calculations were performed using a commercial software (GraphPad Prism version 5.00 for Windows, GraphPad Software, San Diego, CA, USA, http://www.graphpad.com) and a two-sided P < 0.05 was retained for statistical significance.
In each comparison, genes having 'present' detection calls in more than half of the samples in the overexpressed gene group were retained for statistical analysis if they showed >two-fold change between groups.
Only values for gas-phase PAHs collected from XAD-2 resin and particle bound PAHs collected from Teflon filters were retained for statistical analysis (the median nondetect rate for particle bound PAHs on XAD-2 resin and gas phase PAHs on Teflon filters was 97%).
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