Tβ4, the most abundant member in human cells of the thymosin family, has been initially embraced as the ideal actin monomer-sequestering peptide [18], and its function was restricted to regulate actin polymerization of non-muscle cells [19].
First, it highlights that human Tregs are probably not a special subset of self-specific T cells that are restricted to regulate auto-immunity, and thus, that Tregs should be viewed as "counter-response" T cells that only emerge upon long lasting immune responses.
HLA-G expression was first thought to be restricted to fetal trophoblasts regulating NK cells at the fetal maternal interface during pregnancy.
Furthermore, the genes that are similarly expressed between EVT and choriocarcinoma cell lines are related to cell motility, signaling, vasculature and tissue development (all functional signs of differentiation), while HTR8/SVneo and EVT similarities are restricted to those genes regulating RNA transport and metabolism (housekeeping characteristics) [ 31].
The only case in which strict complementarity is observed in organisational change concerns CO2 abatement, a relatively complex type of EI, but this is true only when the sample is restricted to more polluting (and regulated) sectors.
This table is restricted to GWAS-traits with regulated genes outside of the HLA-locus, an extended table including all data is shown as Supplementary Material, Table S4.
Expression of the p110δ catalytic subunit of the phosphoinositide 3-kinase pathway is restricted to leukocytes, where it regulates proliferation, migration, and cytokine production.
In intact Hydra polyps, the expression of neurogenesis genes is spatially regulated, being restricted to the i-cells in the central portion of the body, and that of neurotransmitter genes is highest at the head and foot regions, where the nervous system is densest.
The analysis in COSMIC was restricted to genes that were i) regulated in the same direction in ovarian cancer in at least three of the previously chosen studies or ii) identified in either Futreal et al. [24], or Greenman et al. [25].
The expression of the Znf179 gene is restricted to the brain and is regulated during brain development.
