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High CXCR3 expression was originally thought to be restricted to activated T lymphocytes [22], however, later findings show that expression of CXCR3 can be detected in endothelial cells, dendritic cells, as well as in neutrophils and eosinophils within tissues dominated by Th1 [24], [24].
Thus, CXCR3 expression does not appear to be restricted to activated T lymphocytes, and chemokines may attract more than just T lymphocytes.
Thus, the strongest cellular and tissue responses to i.p. injection LPS in fish are thought to be restricted to activated monocyte/macrophages and lymphocytes, portals of entry (gills, intestine, skin) and acute phase organs (liver).
High CXCR3 expression was originally shown to be restricted to activated T lymphocytes [ 5, 22, 23] and could be observed in resting T lymphocytes, B lymphocytes, monocytes or granulocytes [ 20, 24].
CD248, also referred to as endosialin or tumor endothelial marker 1 (TEM1), is a highly sialylated cell surface glycoprotein [ 10- 12] that has been shown to be restricted to activated stromal and perivascular fibroblasts [ 13- 16]}.
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This is of relevance, because it has been discussed that the different subunits of a G-protein subtype may not be restricted to activating only one signaling pathway [30].
Activity of the S18A promoter appears to be restricted to meristems; plants activate an extra copy of this gene in tissues with cell division activity [ 31].
Our studies indicate that the role of CD4+ T cells in modulating the CD8+ T cell response to the circumsporozoite protein of irradiated P. yoelii sporozoites appears to be restricted to ensuring the survival of activated T cells, without a discernible effect on the development of their functional properties.
Unlike E2F1, E2F3 is unable to activate mTORC1, suggesting that growth activity could be restricted to individual E2F members.
If caspases are activated during mitosis, a critical question is then, how could caspase cleavage be restricted to those cell cycle regulators, while leaving other vital proteins intact?
Indeed, IL-21 production is considered to be restricted to different subsets of human CD4 Th cells [52] and to BCG-activated murine NKT cells [53].
More suggestions(13)
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be linked to activated
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