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However, these broad measures may not be responsive to small but important changes in health status.
This puts a different emphasis on the causes of aneuploidy: that the SAC may not be responsive to small errors in microtubule-kinetochore attachment.
Specific measures designed for evaluative purposes are often able to detect small but clinically important differences among subjects and be responsive to small but clinically important intra-subject changes over time.
In the Not Prevented and Partially Prevented categories, only A2m, Ccr5, and Jak3 gene expression was significantly correlated to %HbA1c (Pearson correlation, P < 0.05), suggesting these genes may be responsive to small increases in %HbA1c such as those observed in the insulin-treated diabetic animals.
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These include the use of native yeast promoters or regulatory elements that are responsive to small molecules such as galactose, methionine, and copper, or engineered systems that allow regulation by orthogonal small molecules such as estrogen.
The network is composed of five genes regulating each other through a variety of regulatory interactions; it is negligibly affected by endogenous genes, and it is responsive to small molecules.
The network is negligibly affected by endogenous genes and it is responsive to small molecules.
Many years ago, Horace Barlow suggested that retinal "off" units, concentrated in the posterior retina of the frog, are well suited to provide accurate information about the position of a fly [ 33], and RGCs that are responsive to small dark objects (but not bright ones) were proposed to function as "bug perceivers" [ 34].
In our study, food intake and fecal output were responsive to small changes in LPS dose with the lowest dose of LPS tested (0.005 mg/kg) resulting in a significant reduction in both endpoints indicating that they are highly sensitive measures of gastrointestinal function.
Predominant accumulations of morpholino-[I]IPQA in EGFR-expressing L858R and E746-A750 del carcinoma tumor xenografts reflect the high level of phosphorylated EGFR expression and activity in those tumor cells, which are known to be responsive to therapy with small molecular inhibitors of EGFR (e.g., Gefitinib) [ 14].
This suggests that smart politicians should be responsive to individuals who give small amounts, rather than to giant corporations and interest groups.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com