Sentence examples for be responsible of mediating from inspiring English sources

On the other hand, CXCL1, but not anti-CXCL8, was found to be responsible of mediating tumor-derived angiogenesis in human DU145 prostate cancer cell line [ 27].

(24) A large number of general acids are typically present in bacteria, one or some of which could be responsible for mediating the protonation of Ea-CAI-1.

Due to the complexity of the structure of oral mucosal biofilms [9], transcriptional deregulation of a single C. albicans gene is unlikely to be responsible for mediating loss of the mucosal biofilm phenotype in the bcr1/bcr1 mutant.

The N-terminal 69 amino acids of Apoptin appear to be responsible for mediating at least some of Apoptin's cell death pathways [ 14], whereas the tumour selective nuclear targeting ability of Apoptin has been localised to its C-terminal domain (amino acids 74 121) [ 15- 17], known as the tumour cell enhanced nuclear targeting signal (tNTS).

Of these dimers, only RXR PPARα, RXR PPARγ, and RXR homodimers bind to the DR-1 element [ 11], suggesting that all or any of these three dimers may be responsible for mediating the inhibitory effect of LG268 on MMP-1 and MMP-13.

It has been reported to be expressed both in airway epithelium and in ASM cells of asthmatics and to be responsible for mediating cell proliferation through activation of EGF receptors (19, 25).

The presence of human immunodeficiency virus type 1 (HIV-1) in the brain is believed to be responsible for mediating the pathogenesis of neurological abnormalities through the viral toxins gp120 and Tat.

GT1-7 cells have been shown to express MCH-R1 mRNA [39], and it has been recently reported that 50 55% of GnRH neurons express MCH-R1 mRNA in the rat, suggesting MCH-R1 receptors may be responsible for mediating the effects of MCH on GnRH neurons [38].

The mesolimbic dopamine system, specifically dopaminergic projections from the ventral tegmental area (VTA) to the nucleus accumbens (NAc), has been studied extensively for its role in mediating the rewarding effects of drugs of abuse and may be responsible for mediating the differences in motivation seen in the bHR and bLR animals.

Each of these cis eQTLs, listed in Tables 2 and 3, respectively, are candidate genes whose expression is strain dependent that could be responsible for mediating the trans regulation of ∼1000 other genes.

After elucidating the signaling components upstream the ERK5 cascade, we examined which one of them may be responsible for mediating the reduced ERK5 phosphorylation upon changes in calcium concentrations.