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The heart contains several cohorts of resident cardiac progenitor cells (CPCs) which have been characterized by different groups [16] [22] and are considered to be responsible for tissue homeostasis [23].
Whereas the secreted members of the proteolytic enzymes are known to be responsible for tissue penetration, in the oral cavity the GPI-anchored proteases may pave the way to tissue invasion by targeting the host substrate comprising the first line of defense against invading pathogens.
First of all, epigenetic factors that might be responsible for tissue- or condition-specific expression should be taken into account.
Hyperactive immune cells, especially T cells, with excessive cytokines may be responsible for tissue injury in KD [ 10].
In a murine model of M. marinum infection, the RD1 region was shown to be responsible for tissue damage through necrosis (Carlsson et al., 2012).
On the other hand, TNF-α has been found in kidney and skin biopsies in SLE and is thought to be responsible for tissue damage [ 38, 39].
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In this context, each tissue consists of a unique ECM composition, which may be responsible for tissue-specific cell responses.
From these data, it can be speculated that rice TFs play a crucial role in overall plant growth and might be responsible for tissue-/developmental stage-specific stress responses.
They are responsible for tissue renewal and repair and can become activated in response to environmental signals such as hormones.
Resident pools of somatic stem cells in many organs are responsible for tissue maintenance and repair.
Although typically not lethal, they are responsible for tissue deformity and substantial morbidity, particularly in high-risk populations.
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