Sentence examples for be responsible for substrate from inspiring English sources
Four residues (i.e., His133, Lys236, Glu316 and Glu324) in the MshA structure were previously demonstrated to be responsible for substrate binding (Vetting et al., 2008).
In this complex hSel-10, rather than parkin itself, would be responsible for substrate recognition.
It can be speculated that DSRM and La-like domains may be responsible for substrate binding by the orthodox HEN1 from plants.
Among these two domains, GST_N contains catalytically essential residues and is thought to be a key component of catalysis in GSTs, whereas GST_C may be responsible for substrate specificity.
We focused on optimization of AcrB, the inner membrane domain known to be responsible for substrate binding, and found several mutations (A279T, Q584R, F617L, L822P, F927S, and F1033Y) that resulted in improved tolerance.
Amino acid residues known to be responsible for substrate recognition in the enzymes from meso-DAP containing bacteria are also conserved in the enzymes from ll-DAP containing bacteria including Streptomyces.
It contains a BTB domain, which serves as an adapter for Cullin-based E3 ubiquitin ligase, and a MATH domain that is responsible for substrate recognition and CUL3-mediated protein degradation5,6,7.
By analyzing the results, active site architecture, certain key residues and pharmacophore common-features that are responsible for substrate specificity were identified on the Kv1.5 potassium channel, which would be very helpful in understanding the blockade mechanism of Kv1.5 potassium channel and providing insights into rational design of novel Kv1.5 blockers.
In addition, it is suggested that Trp225, which is located in the active site, facilitates proper substrate entrance into the binding pocket in contrast to aklavinone-11-hydroxylase and para-hydroxybenzoate hydroxylase in which a residue at a similar position is responsible for substrate deprotonation.
In this process, the E3 ligases are responsible for substrate selection and the specificity of Ub-linkage.
Previous study shows that the TRAF domain binds to P/AxxS motif (from p53 and MDM2) and is responsible for substrate recognition (Sheng et al., 2006).
