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Similar findings may be responsible for progression of osteoporosis in postmenopausal women where chronic menstrual bleeding may persist for up to 35 years [26].
Following the chronic inflammation stage, genetic or epigenetic changes leading to altered expression of other cytokines, growth factors and oncogenes might take over and be responsible for progression of the tumor.
The radicals and enzymes may be responsible for progression of vascular and cardiomyocyte injury [ 54].
This suggests unknown pathophysiologic mechanisms may be responsible for progression of early atherosclerosis in young adults with type 1 diabetes and normal ACR.
Mechanical stress from body weight is thought to be responsible for progression of posterior slip of the epiphysis, leading to groin pain and external rotation of the lower extremity [ 5].
The ability of CSC to self-renew is thought to drive its malignant phenotype and could be responsible for progression of cancer into a more advanced form of the disease.
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This should have resulted in cells undergoing G0 G1 arrest since the protein is responsible for progression through the G0 G1/S phase transition [40].
Generation of oxidative stress-related molecules has been suggested to be one of the 'multiple hits' that are responsible for progression of fatty liver to NASH [ 2, 24].
In addition, there is increasing evidence for the existence of sub-populations of cells with enhanced replicative potential that maintain the disease and are responsible for progression (Messmer et al, 2005; Calissano et al, 2009).
If several genes are responsible for progression of tumors from pT1 to pT4 it is likely that tumor stage, and not one of the many genes influencing tumor stage, will be influential in the multivariate regression model.
It is well known that D-type cyclins are responsible for progression through G1 phase; E-type cyclins for completion of G1 phase and entry into S-phase; A-type cyclins for driving the transition from S-phase to M-phase (G2 phase); and B-type cyclins for cell progression through M-phase (Malumbres and Barbacid, 2009).
More suggestions(14)
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