A Sept. 18 internal report on problems with the guard facility's electrical system, prepared for Charles E. Williams, the director of building operations, suggested that KBR, the former Halliburton subsidiary hired to run the facility, was responsible for overloading the system.
In addition, bicarbonate administration can be responsible for hypernatremia, volume overload, the release of proinflammatory cytokines [ 31] and apoptosis [ 29].
These results made Na+/K+-ATPase (especially its OBS) a potential target in the interaction of cells with cationic nanocarriers that might also be responsible for the intracellular Na+ overload.
Differences in volume status may also be responsible for the difference, as volume overload is more common in CAPD patients than in the normal population [ 16].
For instance, cleavage and inactivation of the plasma membrane calcium ATPase PMCA-4, which removes calcium from the cytosol, disturbs ion homeostasis.28 The subsequent cellular calcium overload may be responsible for the secondary necrosis that is observed in the late stages of apoptosis.
This suggests that other factors may be responsible for the contractile dysfunction that results In overload remodeling.
Lymphatic interruption increases the risk of extravascular lung water accumulation [11] and it may be responsible for pulmonary edema development following even minimal fluid overload [12].
This overload, together with other factors, could be responsible for the onset of secondary lymphoedema.
Endogenous DNaseI deficiency due to a genetic polymorphism in lupus has been postulated to be responsible for inappropriate nuclear debris clearance and results in immune system overload and antinuclear autoantibody generation [ 36, 37].
On the other hand, patients receiving too much fluid may develop complications associated with fluid overload, such as tissue edema, which may be responsible for prolonged mechanical ventilation and delayed wound healing [11].
This makes overload with Cre protein less likely to be responsible for the observed phenotype.
