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For instance, the side chain of K200 could be responsible for interacting with the γ-phosphate of the nucleotide during transition state stabilization; the strictly conserved D285 and E286 residues could participate in coordinating the divalent cation.
This region is not involved in DNA binding, but is thought to be responsible for interacting with the DNA primase and clamp loader proteins [ 31].
If true, this predicts that the N-terminal portion of ATM deleted in tefu ZIII-5190 might be responsible for interacting with a telomere-specific ATM target.
The amino acid residue Tyr is between the Walker B motif and sensor I of the AAA+ domain, which may be responsible for interacting with a conserved arginine residue on an adjacent helix structure [ 3, 4, 51, 55– 55].
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PA is responsible for interacting with cell receptors and for the subsequent translocation of LF inside the cell compartment.
We next tested which region of USP15 is responsible for interacting with BARD1 by expressing BARD1 together with USP15 or its truncated mutants in HEK293T cells (Fig. 2c).
The aryl hydrocarbon receptor (AHR) is one of the principal xenobiotic receptors in living organisms and is responsible for interacting with several drugs and environmental toxins, most notably tetrachlorodibenzodioxin (TCDD).
One player, wearing an Oculus Rift, is responsible for interacting with the bomb.
The RPC Interface is responsible for interacting with the client when registering new applications.
This motif of the protein is responsible for interacting with RNA polymerase and CtIP to maintain proper DNA structure [39].
Among them, K200 is responsible for interacting with the γ-phosphate of the nucleotide during transition state.
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