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We hypothesize that these benefits can be best understood first at the level of key intracellular signaling cascades in the host myocardium, which can be responsible for functional and structural preservation of the heart.
We speculated that surround inhibition in the frontal lobe is a dynamic defense mechanism against seizure propagation and may be responsible for functional deficits observed in MTLE.
Major differences between the three proteins are sequence insertions in loops which could be responsible for functional variations.
In addition, four specificity-determining positions were predicted to be responsible for functional specificity.
Length differences in the loop region are known to be responsible for functional specificity [ 32].
Only then can we possibly correlate the similarities and differences among two clades to be responsible for functional differences.
Similar(41)
In cardiac myocytes, we detected expression of at least 11 Klfs (Table 2), with regulation of several family members from each of the activator/repressor groups by ET-1 (Fig. 1), suggesting that (at least in this system) neither tissue specificity nor classification according to global function is responsible for functional differences between individual Klfs.
Whereas the surgical approach is able to diminish the perceived knee pain of concerned patients', the postoperative recovery is often accompanied by persistent skeletal muscle dysfunctions and atrophy, which is responsible for functional deficits for up to several years.
These changes are responsible for functional alterations and for the accumulation of potentially injurious bioreactive substances.
Interestingly, LMα1LG4-5 domares are not involved in improvement of diaphragm and heart muscle morphology, indicating that other sites of LMα1 chain (most likely integrin α7β1 binding modules) are responsible for functional replacement of LMα2 chain in these muscles.
It remains unclear whether these structural differences are responsible for functional divergences between potassium and sodium channels, for example those that contribute to their dissimilar roles in generating action potentials and accomplishing repolarization in the heart as well as in process of inactivation [30], [31].
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