Sentence examples for be required to downregulate from inspiring English sources
Both p38IP and p38 have been shown to be required to downregulate e-cadherin in the primitive streak and therefore are essential for proper mesoderm migration to occur [ 9].
The histone deacetylase Hdac1 might be required to downregulate the expression of these genes, thereby promoting the responsiveness of blastema cells to regenerative signals in order to ensure correct reconstitution of lost tissues.
Rpd3 histone deacetylase activity is required to downregulate the JNK pathway and it functions in complexes with Sin3A and Sap130 [68].
These results leave open the possibility that ABCA1 is required to downregulate the translocase in apoptotic cells.
In this context, DNp73 is required to downregulate p53 activation of these pathways and its absence results in elevated apoptosis.
In summary, these data indicate that AGO10 is required to downregulate ARF2 transcription from heart to torpedo stages throughout the embryo.
The K48-linked ubiquitin E3 ligase activities of both A20 and Itch are required to downregulate NF-κB activation by TNF.
As it was recently shown that a dual PI3K and mTOR inhibitor is required to downregulate efficiently AKT cell signalling in SKOV3 cells, we chose to work with BEZ235 rather than LY294002.
FI is required to downregulate the alternative pathway of complement activation and complete FI deficiency is associated with a consumptive deficiency of C3 and consequently recurrent infections, not immunopathology (13, 14).
In myogenic cells, previous data has suggested that AP-1 is a negative regulator of differentiation based on observations that c-Jun dimerizes with MyoD to inhibit its activity, and also MyoD is required to downregulate c-Fos for differentiation to proceed.
Support for an involvement of PP2A also derives from the finding that its Bα (PR55α) subunit is required to downregulate the levels of P-Ser552 and P-Ser675 C-terminal phosphoforms of β -CATENIN in colon cancer cells (Zhang et al, 2009).
