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SpCBFβ is a facultative Runx partner that appears to be required specifically for cell differentiation.
The nuclear hormone receptor NHR-80 (homologmolog) has recently been shown to be required specifically for longevity in germline less animals but not for other life extending pathways such as IIS and dietary restriction (Goudeau et al., 2011).
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Another Fox family member, FoxG1, is required specifically for the specification of the ventral telencephalon [ 82], and FoxG1−/− mice display hypoplasia of the telencephalon and excessive production of Cajal Retzius neurons, the earliest born neurons in the telencephalon [ 83].
These new data further strengthen our hypothesis that Bax and Bak are required specifically for MPTP dependent mitochondrial swelling and not non-specific mitochondrial swelling induced by osmotic changes.
We show that enz is required specifically for chromatophore sublineages within the neural crest, and that this requirement is cell autonomous.
Analysis of two newly identified oskar localization factors, Rumpelstiltskin and Lost, that are required specifically for this late phase of oskar localization shows that germ plasm amplification ensures robust abdomen and germ cell formation during embryogenesis.
The unc-76 function is necessary for normal fascicle structure and is required specifically for axon-axon interactions in C. elegans.
However, uropod-localized receptors and ezrin/radixin/moesin proteins still cluster in nocodazole-treated cells, indicating that MTs are required specifically for uropod stability.
Nascent transcription analysis demonstrated that the ΨCTD is required specifically for productive transcription initiation, as an RNAP-II severely truncated within the ΨCTD caused abortive initiation.
These data indicate that within the embryonic neural crest lineage, enz is required specifically for chromatophore development and only after neural crest dispersal and initial differentiation have largely occurred.
No informed consent was required specifically for the present study by the regional research committee.
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