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EZH2 was also shown to be required for viability of ARMS by repressing FBX03224.
As observed by Portnoy et al. (2006), RNase R is the "obvious candidate" for executing mRNA degradation in haloarachaea, and it has been shown to be required for viability and degradation of structured RNAs [103].
These are lipid raft proteins that play important roles in endocytosis (P = 0.047) and actin polarization and are known to be required for viability in stationary phase (Crouzet et al. 1991; Querin et al. 2008).
We selected predicted interactions in which at least one of the proteins was either known to be required for viability after MMS exposure [ 34] or known to interact with an MMS viability protein.
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lin-52 is required for viability, as null mutants die prior to pupariation.
Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection.
We also show that H3K36 is required for viability and H3K27 is essential for maintenance of cellular identity but not for gene activation.
Ideal protein targets are required for viability across many species, are unique to prokaryotes to limit effects on the host, and have robust assays to quantitate activity and identify inhibitors.
Sliding clamp-DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli.
Nevertheless, there are some instances where the uptake of phosphorus by microalgae is greater than what is required for viability.
σE is required for viability of E. coli, yet none of the studies to date explain why σE is essential in seemingly unstressed cells.
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