The analysis by Meng is an important step toward modeling hydrocarbon well proliferation as a landscape process, but a more fundamental understanding and more robust accounting of the factors that influence pad locations is required for a useful treatment of the subject.
An important question from the clinical perspective is: 'how many ECFCs are required for a useful therapeutic dose?' which raises the possibility of expanding and banking ECFC from UCB as a further transplant option.
Such fine-tuning, which is required for functional useful vision, still depends on intact sensory experience and pattern vision during a sequence of hyper-plastic critical developmental periods (Penn and Shatz, 1999; Hensch, 2005; Lewis and Maurer, 2005; Bengoetxea et al., 2012; Espinosa and Stryker, 2012; Voss, 2013; but see also Kalia et al., 2014).
Such studies are more likely to provide the level of specificity and sensitivity which is required for a clinically useful risk prediction tool.
Recently, the real-time PCR provided a major step forward in the power to quantitatively analyse low abundance RNA species (Bieche et al, 1999) and may ensure the specificity that is required for a clinically useful test.
Its user dependency is a limitation; substantial training and experience are required for generating and interpreting useful images during pancreatic cancer surgery.
We also assess where developments are required for them to become clinically useful imaging tests and explore potential new uses for hypoxia imaging techniques including biologically-directed conformal radiotherapy.
Recent findings of plastically bendable molecular crystals led to the realization that design based strategies are required for these materials to be useful in real life application.
A better understanding of traditional classification systems and concepts, possibly combined with a basic training of local monitors in taxonomy, is required for tree identifications to become useful in monitoring either forest biomass, or tree diversity.
Two structural elements are required for a polymer to exhibit useful shape memory: a network structure that defines the permanent shape (the 'memory'), and a switching segment that induces a significant change in the mobility of the network chains.
