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Further modifications would certainly be required for specificity.
Similar(59)
SAM68 proteins have an hnRNP K homology domain (KH domain) that locates within a larger GSG (GRP33-SAM68-GLD1) domais that is required for specificity and high-affinity binding to RNA [ 7, 12].
This high percentage of E3 reflects the specificity that is required for specific substrate recognition.
In addition to the two RNA secondary structures that we have identified, the potential exonic splicing enhancers in the interchromosomal region of the ACAT1 chimeric mRNA, which are important elements of the "splicing code", may also be required for the specificity of this exo-endo trans-splicing; these potential sites warrant further investigations.
Importantly, this truncates the RIG-I C-terminal domain (amino acids 885 1014), thought to be required for RNA recognition specificity (Kowalinski et al., 2011; Figure 1F).
Together, the minimal characteristics of surface markers still appear to be insufficient for defining the precise role of MSC and additional markers will be required for determining tissue-specificity, a selective MSC subpopulation, and the activation status of MSC.
For MRC2 and MRC4, members of the largest RGC family present were shown to be required for the co-segregating resistance specificities.
For example, adhesins are commonly regarded as virulence factors as they allow adhesion to the host cell, and depending on their specificity may be required for the progression of disease in particular tissues [ 83].
Clearly, additional sequence or structural specificity will be required for splicing, but at least for LeuRS the result may be a generic ability to bind to non-cognate mt-tRNAs.
A smaller sample size will be required for a similar precision with a minimum specificity of 75% (n = 52).
Therefore, appropriate tissue specificity is likely to be required for immunotherapy.
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