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Although on a per cell basis more HBV particles seemed to be required for significant immune regulatory effects on purified pDC compared to pDC present in PBMC cultures, the number of HBV genome equivalents per pDC in pure pDC cultures compared to the ±0.3% pDC present in total PBMC cultures was even 10 50 times less (Fig. 2B, 4A).
Our results imply that canopy gaps may be required for significant increases in stem length and hence recruitment from W. nobilis juveniles to canopy trees.
Many of the outcome measures we assessed had low statistical power, and a larger number of dogs/group would be required for significant results in an efficacy clinical trial.
However, the uncertainty added by the source apportionment estimation suggests that longer data records may be required for significant effects to be detectable in source-specific analyses than for PM2.5.
Since inhibition of many kinases may thus not always be required for significant clinical activity in imatinib-resistant GIST, it may be possible to develop well tolerated and yet effective inhibitors for imatinib-resistant GIST.
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Thus, injury to both LSECs and hepatocytes is required for significant hepatocyte elimination.
However, if channel composition is SKE-based, global trusts, which may not be satisfied in the system's name space, are required for significant improvements in performance.
FGF-2 increased DNA content; however, high concentrations of FGF-2 inhibited/delayed osteogenic differentiation, while a threshold concentration of BMP-2 was required for significant osteogenic enhancement.
Simple ice flow modelling indicates that a plateau icefield type glaciation is required for significant ice flow to occur and confirms thin ice cover, in particular on narrow summits, thereby supporting the explanation of tor class distribution.
Here, at least 64 cells per Jeans length are required for significant amplification to occur.
For instance, a vacuum pressure of 0.01 torr or less is required for significant reduction of the heat loss through conduction mechanism (Roth 1990).
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