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Clearly, IGF-IR expression will be required for response to agents that target the IGF-IR.
Thus, although many molluscs show expansions of heat shock gene family members [ 51, 52], these may not all be required for response to thermal stress.
We suggest that cold-related cis-elements may be required for response to cold in roots outside the region contained in the B1S3 construct.
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As these events are responsive to the mechanical properties of the substratum (DuFort et al., 2011), we hypothesized that Cdc42EP3 and septins may be required for responses to changes in matrix stiffness.
S. pombe rad60 is required for response to DNA damaging agents and recovery from S phase arrest [28], [29], [30].
These data indicate that K14, and possibly K30, is required for response of cells to replication arrest.
Although ER expression is required for response to endocrine agents, ER-positive tumours may still fail to respond, e.g., due to cross talk with other pathways.
Interestingly, both NbSERK3 (Fig. 6) and CMPG1 are required for responses to INF1, when this protein is delivered by infiltration into the apoplast of N. benthamiana [7], [32].
Where statistical analysis was required for responses, IBM® SPSS® software was used.
The proximal Sp1 sites of the p27 promoter are required for responses to vitamin D3 [ 63] and tamoxifen [ 64].
We conclude that whereas glutamate and neuropeptide signaling is required for responses to ΔT = 0.4°C, neuropeptides but not glutamate are dispensable for responses at ΔT = 1.0°C.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com