Sentence examples for be required for proteasomal from inspiring English sources
The cysteine has been shown to be required for proteasomal association, and has to be 19 amino acids away from the carboxy terminus of the protein [ 36, 37].
Blocking autophagy flux by HCQ confirmed that p62 is required for proteasomal inhibition-induced LC3 expression and autophagosome biogenesis (Fig. 7h; Supplementary Fig. 8i).
There are two known sequences that are required for proteasomal degradation.
Rsp5 is required for proteasomal processing of a membrane-bound transcription factor (Hoppe et al., 2000).
Because ubiquitylation is required for proteasomal targeting, it is was a surprising finding that either loss of ubiquitin ligases (i.e., leading to decreased ubiquitylation) or loss of DUBs (i.e., leading to increased ubiquitylation) interfered with efficient ERAD.
We then used the different mutant constructs to test whether kinase activity was required for proteasomal degradation and whether the NPHP-disease-associated mutants were also degraded upon serum starvation.
Proteasomal degradation of MCL-1 has been described to be required for microtubule-targeted drug-induced apoptosis, while phosphorylation of BCL-2 during mitotic arrest has been reported as a pro apoptotic or antiapoptotic event depending on the context.
Thus, E3 ligases that support ERAD are required for K48 ubiquitination and proteasomal degradation of VEGFR2 in response to MET signaling.
43 also demonstrated that BubR1 is required for the ubiquitin-mediated proteasomal degradation of CDC20 in the G0 phase and the maintenance of APC/CCDH1 activity.
Although ATP is not required for substrate degradation in the 20S proteasomal core, it is required for maintaining the integrity of the 19S proteasomal regulatory complex, which contains six subunits with ATPase activity.
pVHL acts as the substrate-conferring component of an E3 ubiquitin ligase (pVHL/elongin BC/Cullin-2) and its interaction with HIF-2α is required for the rapid polyubiquitylation and proteasomal degradation of HIF-2α under normoxic conditions11.
