A 12-lipoxygenase in zebra fish (zf12-LOX) was found to be required for normal embryonic development and LOXs are of great interest for targeted drug designing.
Many transcription factors and signaling pathways are known to be required for normal MDNs formation, but a unified model of MDN development is still unclear.
Conversely, the (pro-oxidant) superoxide-generating NADH oxidase activity of Aif may be required for normal muscle regeneration [30].
Cycles of neddylation and deneddylation of Cullins are thought to be required for normal function of Cullin-based ubiquitin ligases [13], [21].
This finding suggests that the activities of the PI3-kinases, PTEN, PLA2, and the guanylylcyclases should be required for normal chemotaxis in shallow gradients.
ACTN4 has been shown to be required for normal podocyte adhesion [10] and mice deficient in ACTN4 have severe glomerular disease presumably due to this altered adhesiveness [9].
In a previous study, a combined dosage of the factors E2A, E2-2 and TCF12 was shown to be required for normal B-cell development.
Slug (SNAI2) shows the highest expression in non-invasive cell lines and may be required for normal prostate differentiation (Figure 5a; Figure S3b).
Therefore, the early expression of VGCC subunits may be required for normal pancreatic β-cell development and in combination with other signals may trigger the further differentiation of endocrine and β-cell lineages.
Under conditions of stress it is thought that intracellular components such as mitochondria are targeted for degradation by autophagy and we postulated that a basal level of autophagy may be required for normal cellular homeostasis in quiescent cultures.
The similar phenotypes of gin4Δ and the shs1-ps mutants, combined with the finding that phosphorylation of Shs1 appears to regulate association with Gin4, suggests that interactions between Gin4 and Shs1 may be required for normal progression through G2/M.
