Sentence examples for be required for mediating from inspiring English sources

Because both PKCzeta and PKB have been proposed to be required for mediating a number of crucial insulin responses, formation of an active signaling complex containing PKCzeta, PKB, and PDK2 is an attractive mechanism for ensuring that all the critical sites on targets such as glycogen synthase kinase-3 are phosphorylated.

LRP1 is also known as transforming growth factor β (TGFβ) receptor V (TβR-V) and appears to be required for mediating the growth inhibitory response of TGFβ, in conjunction with Smad signaling through TβR-II and I [13], [14].

Within the rather divergent regulatory domain, a conserved NAF or FISL motif was identified, which has been reported to be required for mediating CBL interaction [ 6, 7].

NRP2 is known to be required for mediating repulsive actions of Sema3B, 3C, and 3F, whereas NRP1 is known to be required for Sema3A function.

Together, these results suggest that PERK signaling during metabolic stress does not seem to be required for mediating tubular inflammation but could constitute an accessory pathway that promotes tubular inflammation when selectively activated.

The stable binding mode occurs only during and after DNA replication, depends on Smc3 acetylation and sororin binding, and is thought to be required for mediating cohesion from S phase until mitosis [ 23, 36].

In the present report we investigate which Ynd1 protein domains are required for mediating the E4orf4 signal.

Taken together, our findings demonstrate that FASN is a functionally relevant target of p63 and is required for mediating its pro-survival effects.

LRP1/TGFβR V) is required for mediating the growth inhibitory response of TGFβ, in conjunction with Smad2/3 signaling through TGFβR(I) and (II) [13], [14].

The induction and repression of cell death and survival genes, respectively, in response to H2O2 also suggests that activation of NF-κB is required for mediating its pro-cell death response.

As shown in Figure 4B, kanamycin treatment (100 µM) resulted in a significant increase in intracellular chloride concentration in prestin-expressing cells compared to that in control cells, indicating that prestin is required for mediating the kanamycin-induced change in intracellular chloride concentrations.