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Baghdad does not have the billions that will be required for its reconstruction nor is it prepared to deal with the onslaught of refugees that the fighting will create.
While the location of PrPC in lipid rafts is suspected to be required for its conversion into PrPSc [8], [9], it could also have implications as to PrPC function.
Are there conditions such that a cause ceases to be required for its effect, if you imagine them away?
Rather, the interaction of different compounds seems to be required for its overall inhibitory effect on leukotriene production.
Sumoylation of HDAC1 has been shown to be required for its function.
Second, the SA2 domain includes a Nuclear Localization Sequence (NLS; AA 474 479; Fig. 1) shown to be required for its import into the nucleus [42].
ICP27 was also found to interact with Hsc70 (Figures 2 and 3), and to be required for its redistribution to nuclear foci or VICE domains.
However, recent data supports the idea that the formation of intact Dam1-DASH rings around microtubules may not be required for its function [9], [10].
Sumoylation of lipin-1α, in addition to mediating its nuclear localization, also appears to be required for its transcriptional coactivator activity toward PGC-1α and MEF2 in neuronal cells (see paragraph below).
Accordingly, only fetuin-A is known to harbor a unique N-terminal cystatin-like domain which has been shown to be required for its high calcification inhibitory activity [25].
Although the contribution of each domain such as the PUB domain or the mannose-binding domain remains unknown, the fact that the point mutation to the "catalytic" Cys resulted in loss of functionality suggests that some enzymatic function of this protein may be required for its proper function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com