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IgE-Fc conformational flexibility may be required for interactions with two distinct IgE receptors, and the structure suggests strategies for the design of therapeutic compounds for the treatment of IgE-mediated diseases.
Flexibility in the p12 domain may also be required for interactions with host cell proteins involved in late assembly processes, including viral release.
The laminin-binding regions missing in silMUT may be required for interactions important for cell viability.
E2 envelope glycoprotein is known to be required for interactions with cellular receptors involved in endocytosis and membrane fusion.
Interestingly, the N-terminal DNA-binding domain and the C-terminal regulatory domain of c-Myb have also been reported to be required for interactions with CBP (Pattabiraman et al., 2009).
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This further suggests that genes that are important for establishment of infection in the lung may not be required for interaction with immune cell subsets in vitro.
Biotin binding perhaps contributes to structural transitions that may be required for interaction of ATP to form ternary complex between MtBPL, biotin and ATP.
The conserved tyrosine residues in DHRs can be required for interaction between the EAD and Rpb7.
The Dutch mutation resides within amino acids 12-28 of Aβ peptide, a domain which appears to be required for interaction with apoE [ 33].
Furthermore, it has been shown that the N-terminal half of the SANT domain is required for interactions with histone acetyltransferases or histone deacetylases, while the C-terminal half is required for the interaction with chromatin [30], [31], [32].
Some labs have reported that at least one of the RS domains of SF2/ASF and U1-70K is required for interactions between these two proteins [13], [67], but these experiments did not demonstrate that the RS domains of both proteins were required for their interaction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com