Reciprocally, the N-terminal 247 amino acids of Dab2, including the phosphotyrosine-binding domain (PTB), are required for interacting with endogenous LRP6, and this interaction requires Wnt stimulation, in that in the absence of Wnt3A treatment full-length Dab2 could not co-immunoprecipitate LRP6.
One is the Swc2 subunit, which is required for interacting with H2A.Z/H2B dimers.
A hallmark of IκBs is the presence of an ankyrin-repeat domain, which is required for interacting with NF-κB and inhibiting the nuclear translocation and DNA binding activity of NF-κB dimers.
However, only tethering of SCML2A but not SCML2B caused an increase in BMI1 recruitment to the UAS-containing reporter, confirming that the SPM domain is required for interacting with BMI1 and suggesting that SCML2A contributes to PRC1 targeting.
As a steady-state device, active cooling will be required for components that interact with the plasma (targets, limiters, etc)., as well as for other plasma facing components (transport regions, vacuum tanks, diagnostic ports).
The most significant term (based on P-value of GO enrichment test) is rhodopsin-like receptor activity, which are chemosensory receptors in C. elegans and may be required for larval nematodes to interact with their free-living environment.
PHACTR4, a protein recently shown to be required for directed ENCDC migration, interacts with the actin cytoskeleton and protein phosphatase 1 (PP1).
These include the absence of a characteristic tripeptide that is proposed to be required for the Clp ATPase partners to interact with the proteolytic subunit ClpP in E. coli and other bacteria [32] and the presence of three conserved cysteine and a single histidine residue in the amino terminal domain possibly forming a zinc finger motif or a reminiscent thereof.
MYST4 was shown to be required for RUNX2-dependent transcriptional activation, and to interact with P53 in cancer [44], [45].
