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Grubbs' olefin metathesis reaction was utilized to prepare a macrocyclic variant of a linear Grb2 SH2 domain antagonist in an attempt to induce a β-bend conformation known to be required for high affinity binding.
In case of KpnI methyltransferase dimerization has been shown to be required for high affinity substrate binding needed for catalysis [41].
A dynamic chromatin state may be required for high transcriptional competency to maintain pluripotency.
Complete suspension is known to be required for high cellulase activity [ 102].
Furthermore, exo-rhodopsin has been shown to be required for high levels of aanat2 transcription [ 54].
Recently, Fra-1 was also shown to be required for high metastasis in xenografts of a highly metastatic MDA-MB-231 derivative cell line.
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CPR training should be required for high-school graduation.
The present experimental arrangement works particularly well at low frequencies, but more secondary sources will be required for high-frequency noise.
Thus, later imaging time points may be required for high-contrast PCa imaging using 18F-PSMA-1007, which is in accordance with observations made in initial patient studies [10].
Thus, a specific reservoir model for the site will be required for higher accuracy in the future, after we obtain accurately measured geomechanical data and failure models.
Thus our aim is to explore a self-consistent model that makes explicit what would be required for high-fidelity neuronal topology copying.
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