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Although low levels of endogenous mouse HoxB4 expression were detected in c-Kit+CD41+ cells, higher expression levels might be required for generation of HSCs.
NWASP-syndapin interaction may be required for generation of ROBO4-labeled vesicles and endocytosis [ 66].
Whereas T cell help is said to be required for the primary response, experiments with noninflammatory immunogens have demonstrated it to be required for generation of secondary response.
Kcnq1 encodes a potassium channel subunit that is known to be required for generation of the EP and the high K+ concentration, both of which are essential for auditory transduction (Barhanin et al, 1996; Sanguinetti et al, 1996).
This is less than what is predicted to be required for generation of an ATP by substrate-level phosphorylation, and it is assumed that some of the ATP from acetyl-CoA conversion must be reinvested to drive the overall reaction, possibly by reverse electron transport [ 13].
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Hendriks, J. et al. CD27 is required for generation and long-term maintenance of T cell immunity.
Each of the serine phosphoacceptor sites is required for generation of rcDNA, although serine 162 is the most important and serine 155 is the least important of the three.
Based on their ability to visualize particles, Liu et. al. concluded that only N and the envelope glycoproteins were required for generation of particles, however efficiency of release could not be determined using their methods [38].
The TNF family member B cell activating factor (BAFF, also known as BLyS) and its cognate receptor BAFF-R are required for generation and maintenance of the mature B cell pool [20], [21], [22].
Our findings demonstrate that LGP2, though not essential, is required for generation of optimal cytokine responses to intracellular dsDNA, infection with the bacterium Listeria monocytogenes (LM) and the pox virus, modified vaccinia virus Ankara (MVA).
These results indicate that Pak2 is required for generation or homeostasis of peripheral T cells.
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