Sentence examples for be required for functional from inspiring English sources

We also discovered that shDNAs could be adapted to act as surrogate mutant inverted terminal repeats (mTRs), sequences that were previously thought to be required for functional self-complementary AAV vectors.

Although prestin is expected to be required for functional human OHCs, the clinical significance of reported putative mutant alleles in humans is uncertain.

These observations led us to conclude that the overexpression of yNhANT4 was unfavorable, and that further modification of yNhANT4 or the yeast genome would be required for functional reconstitution of yNhANT4 in yeast.

Our results suggest that protection of both cell bodies and nerve terminals in the muscle may be required for functional limb improvements in this model of familial ALS, and provides further data in the rat supporting previous mouse studies showing that the survival of the motor neuron can be independent of muscle innervation [51].

These three are centered among additional genes that might be required for functional denitrification: (i) The nirENJ (Rmet_3168/69/70) and nirCFGH genes (Rmet_2079/80/81, RALME2203), (ii) the norR gene (Rmet_3166) encoding a σ54 dependent transcriptional regulator, and, (iii) the NOS accessory genes nosLYFDR (Rmet_4912/3/4/5/6) and nosCX (Rmet_4918/9).

Additional regulatory factors must be required for functional kinetochore formation de novo on alphoid DNA.

Because sororin is required for functional cohesion, this result suggested that the G2/M checkpoint function of cohesin could be uncoupled from its function in sister-chromatid cohesion.

In Arabidopsis, two other Nramp proteins, NRAMP3 and NRAMP4, are critical in remobilizing vacuolar Mn (and Fe) in leaves prior to the import into chloroplasts of mesophyll cells, and are required for functional PSII10.

Here we identify an ATPase module of subunits that is required for functional specification of the Brahma-related gene associated factor (BAF) and polybromo-associated BAF (PBAF) mSWI/SNF family subcomplexes.

We elucidate a mechanistic link between c-Jun/AP-1 and 923, whereby AP-1 and 923-mediated EDC chromatin remodeling are required for functional EDC gene activation.

This is required for functional verification of sequences of several transmit and/or receive simulations.