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In contrast to the caliciviral TURBS, which contain stretches of non-essential bases between motifs 1 and 2, all of the BM2 TURBS appears to be required for function perhaps due to its shorter length, with sequence-specific and sequence-independent elements.
This could help explain the observed intermolecular interactions between RIN4 homologs in soybean, which may be required for function of the Rpg1-b R-protein [ 26].
This space accommodated one complex IV monomer, suggesting that the dimers seen in the X-ray structures might not be required for function.
Each sequence was manually inspected for the presence of active site residues and other residues known or suspected to be required for function.
We also detected problems with names and E. C. numbers assigned to predicted proteins that were similar to known enzymes but that lacked the active site residues believed to be required for function.
Most symbiont genes have a high AT content (McCutcheon and Moran 2012) and their protein products have low predicted stability (Bastolla et al. 2004), with high concentrations of GroEL and other chaperone proteins believed to be required for function (Fares et al. 2002; Kupper et al. 2014).
Similar(54)
This repeat is preceded by a conserved A/T rich sequence that is required for function.
ATP hydrolysis by Rvb1/2 is required for function; however, the mechanism that drives substrate remodeling is unknown.
Par-6 PDZ regulation is required for function as mutational disruption of Cdc42-Par-6 PDZ coupling leads to inactivation of Par-6 in polarized MDCK epithelial cells.
If the C-terminus of a protein is required for function then this will not be an appropriate method.
We show that all three known type II BMP receptors are expressed by WEHI 274.1 cells but that only ActRIIA and BMPRII are required for function.
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