When analyzing such data, the identification of the associated peptide sequence is required for: Extensive amino acid-level similarity searches or domain identification for GO-based functional classification.
Although two-component biomolecule patterns have been generated by direct-write DPN [52, 84], further equipment modification and operation will be required for fabricating extensive multicomponent arrays.
In his opinion, as ductal carcinoma in situ is a unifocal disease it may be possible to avoid mastectomy in a large number of cases, although increased use of oncoplastic techniques will be required for more extensive resections.
Fine mapping and more extensive data would be required for this locus before a concrete claim can be made that it confers susceptibility to type 2 diabetes.
A threshold of a 50% loss of mature hepatocytes, together with a significant decrease in proliferation of the remaining mature hepatocytes, is required for an extensive HPC activation event (Bird et al., 2008; Katoonizadeh et al., 2006).
As for GEMINI, although our time measurements are different from those reported in the original paper due to the use of different machines, in general a long data loading time (1.5 3 hours) was required for the extensive pre-computation, followed by a very quick data integration phase.
It is likely that the readily accessible xylan was hydrolyzed in the first few hours of hydrolysis and that in order to access the xylan that is more closely associated with the cellulose and 'buried' within the fiber structure, the synergistic interaction with cellulases is required for more extensive xylan solubilization.
Moreover, preventing the starvation-induced decline in intracellular pH severely impaired the ability of yeast to recover from prolonged starvation, suggesting that filament formation by metabolic enzymes is required for survival of extensive energy depletion stress.
Minimal incisions were required for the trocars, and extensive dissection of the abdominal wall structure was not needed.
New BE studies were required for products that needed extensive changes in the formulation composition to achieve a dissolution profile similar to that of the reference product.
