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Therefore, dephosphorylation of the BubR1 KARD domain, which may be required for eventual release of PP2A from BubR1, would rely on another phosphatase molecule.
Stationary adhesions typically occur at endothelial cell junctions and are thought to be required for eventual transmigration of the spirochete into the surrounding tissue (Norman et al., 2008; Moriarty et al., 2012).
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Previously, β-Arrestin 1 was shown to contribute to CXCR4 internalization and signaling in response to CXCL12/SDF-1 [48], and to be required for recruitment of the ubiquitin ligase AIP4 and eventual lysosomal trafficking of the CXCR4 receptor [39].
Both in TBEV and WNV encephalitis, CD8+ T-cells were required for the eventual clearance of WNV from the organism and for mouse survival [ 15, 18].
The related GSE complex (GTPase-containing complex for Gap1p sorting in the endosomes) is required for proper sorting of Gap1p from the late endosome for eventual delivery to the plasma membrane.
E2F target genes are required for progression of the cell cycle and their transcriptional repression results in G1 cell cycle arrest and eventual replicative senescence.
The identification, development, and eventual validation of T cell biomarkers that correlate with product bioactivity and clinical response is a challenging and complex process, but is required for understanding and improving on response rates.
But his task was needlessly complicated last week by a parliamentary vote that would set unreasonable rules for the referendum that would be required to ratify an eventual peace agreement with Damascus.
They also called for the Obama Administration to be required to win formal congressional approval for any eventual deal: "When it comes to the Iranian nuclear ambitions, we strongly believe the most prudent policy would be to verify, verify, verify... never trust".
Novel strategies for control, based on a deep understanding of mosquito biology and evolution, will be required to achieve the goal of eventual malaria eradication.
We've already set out how operators will be required to put aside money from day one for their eventual clean-up and waste storage, and now we're increasing substantially the liability to be taken on by operators".
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