Appropriate, sequential orchestration of each step is required for elaboration of permanent COL I matrix receptive to mineralization.
Here we show that, as in cultured hippocampal pyramidal neurons, Dact1 is required for elaboration of fully complex dendrite arbors in cultured forebrain cortical interneurons.
The parapineal is required for elaboration of left-sided character of dHb neurons, and parapineal-ablated fish show largely double-right-sided habenulae [ 5, 6, 11], in which both left and right nuclei are innervated by mitral cells [ 21].
The parapineal is required for elaboration of dHbl character, and if it is ablated, most left-sided neurons adopt a dHbm fate such that left and right habenulae become largely symmetric with right-sided character [ 9, 16, 18, 21].
As it is seen in A. majus, the late stage development of petal has been shown to be regulated by transcript levels of B- class genes (DEF, GLO) and other transcriptional regulators, and the autoregulation loops of these components were required for elaboration of petal development [ 39].
This raised the intriguing possibility that downregulation of GATA3 and upregulation of T-BET (Th1-specific transcription factor) in IL2 stimulated NK cells is required for the elaboration of Th1 type of cytokines in activated NK cells.
Although our transcriptome array analyses did not indicate whether or both Rac1 and/or Cdc42 affected uPA gene expression, this analysis indicates that the activation of both proteins is required for the full elaboration of increased uPA secretion.
Because the activation of Rac1 and Cdc42 is required for the full elaboration of VEGF expression downstream of oncogenic HRas, we hypothesized that introduction of Rac1V12 or Cdc42V12 protein in MSU-1.1 cells results in an induction of VEGF protein secretion (Fig. 6b).
The experiments described above establish that Akt1 is required for correct delivery of the GluRIIA subunit to the postsynaptic membrane and elaboration of the SSR.
Nodal−/− embryos exhibit a loss of mesoderm and elaboration of ectoderm during gastrulation, suggesting that Nodal signaling is required for mesoderm formation from the primitive ectoderm [46].
