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6) In Figure 3B, the authors show that adding aphidicolin following release from a nocodazole block reduced HDR efficiency in HEK293T cells, suggesting that S-phase entry may be required for efficient HRD-mediated repair.
Since several different pathways are involved in cerebral ischemia/reperfusion injury, combination therapy rather than monotherapy may be required for efficient neuroprotection.
The time for hydrate dissociation becomes longer in the case of a higher hydrate saturation, and depressurization along with other stimulation methods, such as thermal stimulation, may be required for efficient gas production.
Together, our data suggested that the cooperation between Spt16p and Sir1p might be required for efficient silencing at both HM loci and telomeres.
One possible explanation for this result was that additional flanking sequence might be required for efficient binding.
Phosphorylation of S101 is constitutive and has been proposed to be required for efficient phosphorylation of S65 [28].
These data indicate that vRNPs utilize MT structure for their translocation inside the cytoplasm, which is likely to be required for efficient assembly and release of progeny virions.
These results indicate that further PBj-specific factors in addition to the Vpx protein might be required for efficient transduction of primary human monocytes.
These results provide some evidence that the cyst is the infectious agent that transmits the infection and also may be required for efficient replication in the mammalian hosts.
CAMLG was found to be required for efficient EGF receptor recycling in studies from CAMLG wildtype and knockout primary fibroblasts [30].
Moreover, it opens the possibility that not only transcriptional activation, but also repression via Erg1 might be required for efficient replication of the virus.
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