Sentence examples for be required for efficacy from inspiring English sources
Preclinical studies demonstrate that, depending on the timing of the intervention, antibody effector functions mediated by the Fc region may not be required for efficacy [ 3, 29- 31].
Chronic dosing of propranolol may be required for efficacy; therefore, we tested the efficacy of chronic treatment with either propranolol or phenytoin on RTT mice.
They concluded that telcagepant is unlikely to block CGRP action in the CNS and that CNS penetration is unlikely to be required for efficacy.
Molecules may have distinct functions in different cellular contexts, therefore rigorous target validation is critical [ 260, 261]; if a signalling protein has a scaffold function, disruption of protein-protein interactions may be required for efficacy.
These and other clinical failures summarized elsewhere,, underscore the complex nature of S. aureus pathogenicity and suggest that a multiantigen vaccine designed to address major bacterial pathogenesis mechanisms will be required for efficacy.
However, acute treatment with the β-antagonist propranolol has been previously shown ineffective in preventing these cardiac problems in RTT mice, suggesting that chronic treatment might be required for efficacy.
In order to determine whether daily gel use was required for efficacy, we tested the activity of the two most protective gels, MIV-150/zinc acetate and zinc acetate alone, when applied every other day for 4 weeks, followed by virus challenge 24 h after the last gel.
Emerging data suggest that differential inhibition of select HDAC enzymes is required for efficacy among different tissues, and much emphasis has been placed on developing selective HDAC inhibitors to improve efficacy.
Progestins are a recommended treatment for the pain associated with endometriosis, but a number of agents in this class are associated with androgenic effects and weight gain at the doses that are required for efficacy [ 8].
Clinical trial of tolDC therapy will ultimately reveal tolDC efficacy; however, localised administration of tolDCs to the arthritic joint will facilitate high tolDC/matDC ratios, which may be required for clinical efficacy and the re-induction of T cell tolerance.
