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For example, basal ganglia signals might be required for driving the cerebello-thalamo-cortical circuit into tremor only during the early phases of the disease.
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Myosin IIB is required for driving the outgrowth of the neuritic processes and the role of myosin IIA is implicated in mediating neurite retraction [27] [30].
Metabolic alterations constitute a hallmark in cancer cells: They are required for driving transformation, progression and spreading cancer in tissues [16].
Moreover, we have demonstrated that p130Cas is required for driving invasion and metastasis formation of HER2-transformed cells [ 10].
Precise conditions are required for driving cells into specific pathways leading to new lineage formation (reviewed in Murry and Keller and Cahan and Daley).
We have shown that CCL2 is required for driving LPS-induced activation of macrophages, and that CSF-1, secreted from cancer cells, induces polarisation of macrophages.
Intriguingly, in addition to the 3 clinical cases showing a correlation between MAPK7 amplification and high level protein expression (IHC3+), we also identified a further 12 cases with IHC3+ protein staining in the absence of MAPK7 amplification, raising the question of whether MAPK7 gene amplification, protein overexpression, or both, are required for driving tumor proliferation.
This might not be surprising because p97/VCP binding is principally thought to be required for providing the driving force for dislocation of substrates form the ER and might not be essential for gp78-mediated degradation of cytosolic substrates like mutant htt proteins.
Quantitative overall heat transfer coefficients that are a function of heat flux and temperature driving force will be required for the design and scale-up of chemical heat pump reactors.
We selected a core set of 69 metabolic genes for quantitative analysis (Additional File S6), which included genes that may be required for adaptation to the host cell by driving metabolism, energy and pH homeostasis.
It comprises brief assessments designed to target essential functions that are required for safe driving including: vision; cognition; and motor skills.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com