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INT has additionally been reported to be required for developmental functions in vivo.
The Nucleosome Remodeling and Deacetylation (NuRD) corepressor complex is an example of a transcriptional modulator that has been shown to be required for developmental transitions of pluripotent cells in both peri-implantation stage embryos and ESCs (Kaji et al., 2006, 2007; McDonel et al., 2009).
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The expression of let-7 family is required for developmental timing and tumor suppressor function, but must be suppressed for the self-renewal of stem cells.
In Drosophila, studies with cohesin mutants demonstrated that cohesin is required for developmental axonal pruning [28] and abnormal cohesin complex cleavage alters wild type larval locomotion [29].
Apoptosis is required for developmental morphogenesis and disruption of this pathway can lead to developmental defects.
Taken together, these results indicate that VEGF-C is required for developmental and early postnatal lymphangiogenesis.
Our results thus clearly show that Cxcl12 produced by nestin+ MSCs is required for developmental HSC migration to bone marrow.
At least one gene, a MADS-Box gene RIN, is required for developmental regulation of ripening, and another, TAG1, is implicated in fruit development [ 14, 15, 28].
Cxcl12 is produced by several stromal cells and is required for developmental bone marrow colonization by HSCs (Ara et al., 2003).
This mechanism involves c-Jun N-terminal kinase (JNK) signaling, which is required for developmental apoptosis of specific neurons during embryogenesis.
The authors tested this idea with the MAP3K Slpr, which is required for developmental signaling, and Tak1, which contributes to immune activation via the JNK and Imd pathways.
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