"The great Iranian people have been repressed for many years.
Other studies have also demonstrated the important role for the PcG machinery in silencing genes that must be repressed to maintain self renewal and pluripotency, and that become activated during differentiation [10], [40].
We have recently reported that EndoG is important for DNA degradation in cardiomyocytes, where the caspase-dependent pathway is repressed during differentiation and is not re-expressed during experimental ischemia [25].
Accordingly, over a dozen known zinc finger transcription factors are elevated with pluripotency and are repressed with differentiation [37] [39].
TERT is expressed in undifferentiated ESC, but is repressed during differentiation (Armstrong et al., 2000).
In ESC cells, differentiation genes are repressed through both DNA methylation and repressive histone modifications.
Obviously, differentiation was repressed again after adaptation and the balance returned to enrichment of pluripotent cells.
Notably, HOX genes are repressed in pluripotent cells and activated upon differentiation.
Consequently, genes associated with naive pluripotency are induced and genes characteristic for a differentiation-primed state are repressed in ES cells overexpressing Prdm14.
Interestingly, let-7 is repressed in ESCs but rapidly upregulated during ESC differentiation (Newman et al., 2008; Viswanathan et al., 2008).
