The definition of progression used for this report (≥2.5 square root transformed units) has been shown to be representative of actual progression and is <1% likely to be due to interscan variability (23, 24).
Also consistent with the RPPA data was the reduction in phosphorylated Akt at day 7. Changes observed in Chk2, p27, and CDC25C may be representative of the disruption to cell cycle progression.
The results of our study indicate that, under the influence of heredity and genetic factors [ 42, 51, 53], gender and/or local factors associated with aging may play a role in disc height narrowing, which is representative of the progression of degenerative structural changes in IVD tissues.
Our studies and others demonstrate that orthotopic models of heterotransplanted human RCC cells are representative of human RCC progression and preserve the karyotypic and histological characteristics of the human primary tumor [ 6- 9, 20].
In fact, any metastatic accessible tissue, either fresh or archival, regardless of the timing of metastasis and site of melanoma progression, being representative of the final BRAF mutational status of disease in a given individual, could be safely utilized to identify patients who are candidate to BRAF inhibitors.
Within this panel, mdr1 mRNA biosynthesis and surface localisation of Pgp were assessed with respect to MDR functionality where the cell lines are representative of different clinical stages of tumour progression, metastatic potential and differentiation.
Values are representative of three independent experiments A decrease in cell viability can be achieved by inhibiting cell cycle progression and/or by inducing cellular apoptosis.
