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For each search, we provide users with the option to use checkmark buttons to define how many and which nucleotides of the query Q comprise the seed and, thus, must be identically present in all off-target sites to be reported, to select a PAM sequence to use, the maximum desired number of mismatches, and whether to report genomic annotation information at the off-target sites.
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These findings may be of particular interest as other common drugs employed in non-neoplastic diseases that are substrates for the ABC transporters have been reported to select for increased ABCB1 in tumour cells following in vivo treatment (Herzog et al, 1993) and to confer resistance to doxorubicin in a tumour system (Granzotto et al, 2004).
In 2006, Neel Tushar Kashkari of Stow Ohio was reported to be selected as one of the regional finalists for the White House Fellows Program.
The C316Y amino acid substitution has been reported to be selected in both subtype 1a and 1b replicon cells.
Highly macrolide-resistant enterococci have previously been reported to be selected by treatment with clarithromycin and metronidazole as evidenced by the increase in erm(B) levels in cultured enterococci after treatment [10].
Active demethylation has also been reported to be targeted to select gene regulatory regions during neurogenesis, memory formation, and immune response (Bruniquel and Schwartz 2003; Miller and Sweatt 2007; Ma et al. 2009).
"Ben is very good at making decisions — none of this waiting for the definitive academic paper before acting," said Geithner, who last week was reported to have been selected as Treasury Secretary by President-elect Barack Obama.
In addition, perturbations in C5aR signalling during rodent brain development have been reported to result in select defects28,29, suggesting widespread roles for complement fragments C3a and C5a in neuronal development.
HIV infection has been reported to occur in select blood groups in some regions of the world.
In higher organisms, enzymes containing GST activity have been reported to also confer resistance to select arsenic species via reductive mechanisms distinct from that of GstB.
Pancreatic metastasectomy of RCC was reported to improve survival in selected patients [ 6- 8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com