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Presumably this altered conformation does not prevent the recruitment of coactivators elsewhere on the receptor or alternatively is capable of binding to novel proteins/coactivators which may not normally be reported to interact with the AF2 domain.
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Secondly, to our knowledge none of the present top interactions have previously been reported to interact in risk for MDD.
More recently, Scribble and Lgl2 have been reported to interact directly in polarised mammalian epithelial cells, although this interaction has not yet been reported in other experimental systems.
When these interactions were compared to those between Arabidopsis orthologs, AtMKK9 was reported to interact with AtMPK10, 17 and -20 in Y2H [ 56].
Since several binding partners have been reported to interact with the C-terminus of FLNa molecule, these mutations may perturb their interaction as well [1], [26].
Interestingly, many of them have been reported to interact with other viruses.
In a recent study, two huNoVs (GII.4 and GI.3) were reported to interact with gangliosides38, including GM3, GM2, and GM1a/b.
ACBD3 is a Golgi resident scaffolding protein52 that has been reported to interact with 3A proteins from several +RNA viruses including the Aichi virus5,21,24,25,53.
PBPs have been reported to interact with various members of both the divisome and the elongasome within the periplasm and the bacterial membrane.
A murine monoclonal antibody, 14B7, has been reported to interact with domain 4 of PA (PAD4) and block its binding to CMG2.
Respiratory chain complexes were reported to interact with each other to form supercomplexes, even megacomplex (Guo et al., 2017).
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