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However, these results remain to be replicated in human fibroblasts.
Rodent human disparity increases the burden of proof that a particular finding has inter-species relevance, necessitating that certain findings be replicated in human experimental models [ 54– 54].
To test whether PDGFRβ upregulation by SESN2 inactivation could be replicated in human lung fibroblasts, we transduced embryonic lung-derived MRC5 cells and adult primary pulmonary fibroblasts with SESN2-shRNA-encoding lentiviruses.
Clearly, further studies are warranted to ascertain whether the potential visual benefits of donor cross-linking for keratoplasty, as demonstrated here in the porcine eye model, may be replicated in human keratoplasty surgery.
It is not known whether the regenerative capacity demonstrated by these c-kit-positive stem cells can be replicated in human lung, and indeed whether the tissue produced will function as normal lung.
One critique to the current study would be that PAI-1 effects in mice may not be replicated in human or other large animals as previously demonstrated that knockout PAI-1 mice did not demonstrate the same findings as patients with PAI-1 deficiency [ 53].
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The authors caution that a "big if" remains over whether the findings would be replicated in humans – and whether cognitive deficits as well as visible symptoms of the disease would be improved.
Within 5 years, scientists say, they may be able to know whether the same result can be replicated in humans. .
The findings have yet to be replicated in humans, but they are already helping scientists understand the triggers of metabolic syndrome, a cluster of conditions associated with obesity.
If this state could be replicated in humans, said cardiologist O. Lynne Nelson of Washington State University, Pullman, who was not involved in the research, it could help patients with impaired heart function live a more active life.
Prof Alan Silman, of Arthritis Research UK, which is funding Dr Davidson's work, said: "Until now research has failed to show that food or diet can play any part in reducing the progression of osteoarthritis, so if these findings can be replicated in humans, it would be quite a breakthrough.
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