These data suggest that further studies with VPA are warranted, although clearly such findings must be replicated in randomized, controlled efficacy studies.
Clearly, it is essential that these studies of CD4+ T-cell reconstitution be replicated in larger, controlled patient cohorts, including patients with and without liver disease, to more clearly define the general applicability of ABM infusion in the presence of highly effective antiretroviral therapies.
Regardless, our results will be limited to CLBP patients and will need to be replicated in randomized control trials with a larger sample size.
This finding needs to be replicated in further carefully designed randomized controlled trails, but it does raise the possibility of the involvement of telomerase as an important biomarker for mind body interventions.
The WHEDA-study evaluates whether the improved effects on daily functioning in people with dementia, found in a Dutch RCT within a community occupational therapy programme, can be replicated in a single blind German randomised controlled multi-centre design with prolonged follow-up assessment.
The environment can be more carefully controlled, measurements can be replicated in genetically identical animals, and the proportion of the variability explained by genetic variation is increased.
Although encouraging, these results should be replicated in independent Ashkenazi Jewish patient and control cohorts once larger sample sizes become available.
Firstly, the main findings need to be replicated in independent samples including unrelated controls and it is to be determined, whether there is an association in a task-specific manner or across tasks.
We now (1) determined whether this finding could be replicated in a new sample of cases and controls, and (2) analyzed HA sub-scores (HA1−HA4) to further understand case control differences.
44 Moreover, any association between a chromosomal region, a specific gene locus, or a single gene variant should, if ever possible, be replicated in one or more separate patient and control cohorts, 10 although differences in ethnic background, treatment procedures, environmental factors, and socioeconomic influences may weaken or even hide any significant findings.
