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The pen effect includes systematic effects other than that of the treatment, which is why pens must be replicated and randomized.
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The experiments were replicated and randomized in order to minimize the effect of unexplained variability in the actual responses due to extraneous factors.
Pens must be replicated, randomized, and included in the statistical model to ensure valid statistical inference.
These data suggest that further studies with VPA are warranted, although clearly such findings must be replicated in randomized, controlled efficacy studies.
Breeding trials to select lines for further investigation do not need full replication and randomization, yet for an assessment of the ecological behaviour of such lines, replicated and randomized ecological experiments would be required.
We feel that our outcome findings must be replicated in double blind, randomized, placebo-controlled prospective outcome studies with large numbers and various populations.
Such subgroup analyses indicate that the results are no longer based on a true RCT, and therefore may yield inflated effect sizes that have to be replicated in independent trials randomized with stratification across number of risk factors.
However, these early findings of efficacy in symptom amelioration should be replicated in an adequately powered, randomized, placebo-controlled double-blind design.
This finding needs to be replicated in further carefully designed randomized controlled trails, but it does raise the possibility of the involvement of telomerase as an important biomarker for mind body interventions.
And it could be replicated in 2020.
The treatments were replicated three times, and laid out according to a Randomized Complete Block (RBD) design, with plot dimension of 3 m × 3 m.
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