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But there is also evidence that some of the core genes in prokaryotes might be replaced during evolution [ 37- 39].
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37 Furthermore, it was recently shown that the SAM domain of Dp53 was replaced during evolution by a helix domain which also supports oligomerization.
That no mitochondrial-type IscS/U proteins have thus far been identified in E. histolytica would suggest that its original mitochondrial-type iscS/U genes were replaced during the course of evolution by the more recently acquired bacterial homologs.
How many managers have been replaced during the current crisis?
The reason could be that DsbA is possibly replaced during evolution by another enzyme with similar function, such as DPI or other proteins in the thioredoxin family.
This index is known to take into account the ability of an amino acid to be replaced by another during the course of evolution.
Thus, sequence analysis revealed that Arg145 can be replaced by non-conservative amino acids during the evolution of this enzyme (Arg145 is aligned with Cys, Val, Gln, Glu, Lys, Ile, Asp, Pro and Thr, based on the alignment reported for the lysozyme at the Dali server [25]), and yet our method identified this residue as critical for the protein function.
The evolution of steroid receptors can be replaced in the more general context of ligand-nuclear receptor co-evolution.
On the basis of this observation, it has been proposed that cyt c6 is the older ancestor, which has been replaced by plastocyanin during evolution due to the shortage of iron in the environment.
The water was replaced once during the rinse.
Medium was replaced daily during this preculture period.
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