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(A) In human cells, DSBs may be repaired through the double-strand break repair (DSBR) pathway or the non-crossover synthesis-dependent strand annealing (SDSA) pathway.
These biases can be repaired through the systematic establishment of new protected areas, and many of the most valuable areas coincide with high priority ecosystem components and irreplaceable elements identified in the Cape Action for People and the Environmental conservation plan.
Evidence indicates that the VCM (vinyl chloride monomer) derivatives etheno-DNA adducts can be repaired through the BER pathway [ 25].
The concomitant DSBs created by I- SceI are expected to delete the Bar gene, and the broken ends would be repaired through the DNA repair process.
The most common DNA lesion in neurons results from oxidation of nucleic acids, such as 8-hydroxy-2′-deoxy-guanosine (8-oxo-G) species, which can be repaired through the base-excision repair (BER) pathway (reviewed in Coppede, 2011).
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The addition of thymidine results in DNA damage within replication forks, damage that is repaired through the process of homologous recombination.
These two kinds of O6-alkylG adducts, O6-chloroethylG and O6-methylG, are repaired through the action of O6-methylG-DNA methyltransferase (MGMT) [5].
It is important to note that short NCOCTs do not mutually exclude the possibility that some of the DSB are repaired through the sister chromatid.
An alternative hypothesis is that a substantial fraction of meiotic DSBs is repaired through the (identical) sister chromatid and thus does not lead to GC.
In S regions, most of the Ig-CSR-induced DSBs are repaired through the conventional non-homologous end joining (c-NHEJ) pathway [ 24, 25].
We confirmed that arsenite induces at least two types of DNA damage: chromosomal breaks and lesions that were repaired through the same pathway as UV-induced photoproducts.
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