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The resultant DNA damage must be repaired effectively in order to maintain genomic stability and avoid malignant transformation.
Moreover, the persistent single-strand breaks (SSB) formed upon PARP-1 inhibition cannot be repaired effectively in the absence of functional BRCA1 or BRCA2, resulting in accumulation of chromosomal abnormalities, cell cycle arrest and apoptosis [ 8, 9].
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Importantly, histone modifications augment DNA damage in a manner that goes essentially unrepaired in many cancer cells, but is repaired effectively in normal cells.
In congruence with APE activity, DNA lesions induced by melphalan were repaired effectively in RPMI-8226/LR5 compared to the parental cells which partially explained the differential sensitivity to melphalan.
It should be repaired in two weeks.
It's happening at a pivotal moment for Boeing, which is eager to show that even significant damage to a carbon-composite plane like the 787 can be repaired as quickly and effectively as in the old aluminum models.
Extremely severe bites that resulted in the loss of tissue such that a doctor could not close up effectively can be repaired with plastic surgery.
The cracks in venture can't be repaired that quickly.
Both narrow and wide dormant cracks (in dormant cracks width does not change over time may be repaired by routing and sealing, which is the simplest and most common technique for crack repair. Narrow, dormant cracks may be effectively sealed by epoxy injection (Do and Kim 2012; Iowa Department of Transportation 2008; Rodler et al. 1989; Leivo et al. 2006).
"They can be repaired.
The meniscus is dimorphic tissue, and it is very likely that an injury located in the outer one-third of the meniscus (red zone) is repaired more effectively than an injury in another area, thanks to the red zone's dense blood vessels.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com