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However, epigenetic changes related to obesity and diabetes cannot be reliably studied in cell cultures or in cells from other animals.
However, the lesson from the Symplicity HTN-1,-2,-3 saga is that the effectiveness of renal denervation can only be reliably studied in a sham-intervention controlled study design [ 12].
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However, according to literature data, FEEST-like procedures could be reliably applied in studies of adolescents [ 37, 44].
We find that net gene gains can be reliably measured in presence absence studies of large populations.
Future studies should include a larger number of EBV miRNAs in methodological evaluations to refine EBV miRNA expression/detection technology to the point where it may be reliably employed in epidemiologic studies.
It should be mentioned that in some patients the diagnosis of BM was based on this elevation in CSF cell count, so the role of this parameter as an independent indicator of BM cannot be reliably evaluated in this study.
The selection differential can be reliably estimated in our study population because almost all the fish are harvested within their first years of life, i.e. few fish escape fishing mortality.
Certainly the relative risk trend projected from international correlational analyses (Table 1) is modest enough to be well within the range that may not be reliably detected in observational studies, regardless of their size, on the basis of the reasons listed above.
Lack of convergence in the literature on effective care management practices suggests that factors contributing to high performance may be highly context-dependent or that the factors involved may be too numerous or their implementation too nuanced to be reliably identified in observational studies.
This is most likely due to higher quality sequence data and higher total reads per patient (DNA fragments sequenced for which their chromosome of origin could be reliably identified) in this study (average 19 million without repeat masking) using the Illumina HiSeq 2000 platform, compared with those achieved using the Illumina GAIIx platform (average 4.6 million reads without repeat masking).
Results show that the non-Gaussian effects of 3He gas diffusion in healthy rat lungs are directly attributed to the anisotropic geometry of lung microstructure as predicted by the Yablonskiy model, and that quantitative analysis over the entire lung can be reliably repeated in time-course studies of the same animal.
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