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The phosphorylation of proteins cannot be reliably determined in post-mortem tissue due to rapid dephosphorylation, which can affect the expression of phophorylated active forms.
Peritumoral infiltrate could not be reliably determined in all patients, because of the absence of invasive front in several tumor samples.
It is critical that there are methods by which Akt activity can be reliably determined, in the particular tissue and pathological condition being examined or treated.
As efficacy can not be reliably determined in the absence of a control group, a case series observation determining 'efficacy' has limited value.
However the individual MTD could not be reliably determined in seven patients who were withdrawn from the study during the titration phase for reasons not related to treatment.
Furthermore, in the context of clinical trials, experienced readers are required to interpret the films, often using time-consuming methods [ 2], and structural change cannot be reliably determined in less than 6 12 months.
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As recipient lineages cannot be reliably determined for recombination events in the lineage I and II ancestral branches, we only analyzed recombination events in the external branches (Fig. 4).
Isocitrate dehydrogenase (IDH) activity in the cytosol could not be reliably determined due to lack of information in directly connected metabolites citrate and AKG, but also because it affects the labeling pattern in the same way as the mitochondrial isozyme.
Assuming zygosity could be reliably determined by physical similarity (89% correctness in our data), no difference in mean HbA1c was observed between MZ and DZ twins (P = 0.56).
IC50 values for TAF672 could not be reliably determined because of its low solubility in DMSO and aqueous buffers, however, it can be expected to mirror the potency of TAF089 since the moiety that interacts with the FAK kinase is identical for both inhibitors.
For example, whether or not the administration of a postoperative anti-emetic was prophylactic or therapeutic could not be reliably determined and therefore was not used in the analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com