Furthermore, rs2071287 and rs3131296, which display very strong LD with each other, were identified as the SNPs that are most likely to be functionally relevant to SCZ etiology, suggesting that it is necessary to determine the association of rs2071287 with SCZ [ 12, 13].
Thus, even if there were differences in the kinases' specificities for Serine versus Threonine, which does not seem to be the case (Francesc Posas, personal communication), it is unlikely to be functionally relevant to the phosphorylation process's influence on system deactivation.
Thus, a total of 68 (unique) genes were found to be functionally relevant to the set of known biomarkers.
A C→T mutation at nucleotide 677 leading to a valine substitution for an alanine (677C > T, rs1801133) is reported to be functionally relevant to MTHFR enzymatic activation, homocysteine levels, and thrombotic events [ 12, 13].
Within 10 Mb centromeric from these microsatellite markers, there was a region containing clusters of enzymes that were very likely to be functionally relevant to RA-specific autoantibody production.
However this approach tends to neglect those genes that are not differentially expressed and typically categorised as being unimportant, although they may be functionally relevant to the particular biological process under investigation.
There is increasing evidence that common variation in the mitochondrial DNA (mtDNA) may be functionally relevant to the development of a range of common diseases.
RGS10 was upregulated and is functionally relevant to microglia quantity and cell death of neuronal hybrid cells.
Cortactin is a ubiquitously expressed Src substrate that engages in several protein protein interactions that may be functionally relevant to tumoral progression.
In such studies it will be important to determine which genomic modifications are redundant and which are functionally relevant to the disease.
