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If IgG3 antibodies are indeed a marker of recent DENV exposure, it will be relevant to explore how changes in the repertoire or functional properties of cross-reactive antibodies in the months following DENV infection contribute to vulnerability to, or protection from, subsequent infection by ZIKV.
In some cases it could be relevant to explore how far potential users were involved at this stage.
The set up of this host-pathogen interaction system should be relevant to explore other pathogen factors contributing to the modulation of systemic immunity (see below).
In latter cases it could be relevant to explore switch-like interpolation schemes and investigate whether the computational model can exhibit bistable behavior [ 41- 45].
As a last remark we would like to point out that if the goal of the experiment is to discriminate between models, alternative approaches (Skanda and Lebiedz, 2010) could be relevant to explore.
For SN-38, the poor precision observed whatever the method of dose calculation used suggests that it may be relevant to explore the causes of interindividual PK variability, before administrating irinotecan (Deeken et al, 2008).
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The circadian properties of organoids will also be relevant to exploring recently uncovered connections between gut microbiota, circadian rhythms and epithelial homeostasis in isolated intestinal epithelial cells (Mukherji et al., 2013).
Therefore, it is relevant to explore the experiences of key actors linked to the environment.
It is relevant to explore these polymorphisms because certain carcinogenic exposures such as nitrosamines are implicated in the risk of gliomas.
From these perspectives, it is relevant to explore and analyze the preferences and attitudes of rural households with regard to the existing biomass fuel resources, market strategies and their acceptability.
"Where people have spent decades practicing their meditation, and gurus have people doing yoga for hours a day, we thought it was relevant to explore spirituality in the age of the app," Aramique says, "where you could reach enlightenment by pulling a VR headset over your face and disappearing while people watch you float in bizarre acrylic structures".
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